Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome.
Identifieur interne : 000117 ( Main/Exploration ); précédent : 000116; suivant : 000118Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome.
Auteurs : Taylor Kain ; Patrick J. Lindsay ; Neill K J. Adhikari ; Yaseen M. Arabi ; Maria D. Van Kerkhove ; Robert A. FowlerSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2020.
Abstract
Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.
DOI: 10.3201/eid2606.200037
PubMed: 32213260
Affiliations:
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Lindsay</name></author><author><name sortKey="Adhikari, Neill K J" sort="Adhikari, Neill K J" uniqKey="Adhikari N" first="Neill K J" last="Adhikari">Neill K J. Adhikari</name></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name></author><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="eISSN">1080-6059</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Adhikari, Neill K J" sort="Adhikari, Neill K J" uniqKey="Adhikari N" first="Neill K J" last="Adhikari">Neill K J. Adhikari</name><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><name sortKey="Kain, Taylor" sort="Kain, Taylor" uniqKey="Kain T" first="Taylor" last="Kain">Taylor Kain</name><name sortKey="Lindsay, Patrick J" sort="Lindsay, Patrick J" uniqKey="Lindsay P" first="Patrick J" last="Lindsay">Patrick J. Lindsay</name><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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